The only difference is the length of the handle. The total length of the C222 is 7.5 inches, while the S217 is 5.5 inches. I prefer the S217 because it's great for travel and easier to use. I can't get too close to the mirror when I'm using the C222 or the handle will hit the mirror.
The C222 costs $2.80 at CrownBrush.com, while the S217 is $1.87